W. Dwyer

Acyl-CoA dehydrogenase substrate promiscuity limits the potential for development of substrate reduction therapy in disorders of valine and isoleucine metabolism

This study investigates whether inhibiting ACAD8 and SBCAD can reduce toxic metabolite accumulation in valine and isoleucine metabolism disorders, finding that MCPA inhibits multiple ACADs and partially rescues lipoylation defects in ECHS1-deficient cells.

Plant Metabolic Network: A multi-species resource of plant metabolic information

The paper updates the Plant Metabolic Network (PMN) with 126 genomes and tools for analyzing metabolism across species, revealing distinct metabolic groups and demonstrating applications in drought tolerance and cell-type specific metabolism.