B. Xue

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo

This study shows IL-13 protects airway epithelial cells from SARS-CoV-2 infection in vitro but worsens disease severity in mice through eicosanoid signaling.

A predominately pulmonary activation of complement in a mouse model of severe COVID-19

This study identifies pulmonary complement activation in a mouse model of severe COVID-19, showing local complement production and its role in lung injury.

SARS-CoV-2 infection unevenly impacts metabolism in the coronal periphery of the lungs

This study shows SARS-CoV-2 infection causes greater metabolic disturbance in peripheral lung tissue than central tissue, despite higher viral loads in the center.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

Dynamic trait distribution as a source for shifts in interaction strength and population density

The paper studies how dynamic trait distribution within a population affects species interactions and population density through ecological processes.

Climatic and biogeographic processes underlying the diversification of the pantropical and early divergent angiosperm family Annonaceae

This study investigates how climate and biogeographic events influence diversification in Annonaceae, finding global temperature significantly impacts diversification rates and suggesting a shift from museum to recent cradle models.

Photosynthetic acclimation mediates exponential growth of a desert plant in Death Valley summer

This study shows Tidestromia oblongifolia rapidly acclimates to extreme heat by altering gene expression, organellar dynamics, and photosynthesis.

A genome-wide overexpression screen reveals Mycobacterium smegmatis growth inhibitors encoded by mycobacteriophage Hammy

The paper identifies 24 gene products from Mycobacteriophage Hammy that inhibit Mycobacterium smegmatis growth through a genome-wide overexpression screen.

Perinuclear force regulates SUN2 dynamics and distribution on the nuclear envelope for proper nuclear mechanotransduction

This study uses single-molecule imaging to show SUN2 dynamics and distribution on the nuclear envelope are regulated by actomyosin contractility and laminA/C network, affecting mechano-sensitive gene expression.

Pre-existing immunity to influenza viruses through infection and/or vaccination leads to viral mutational signatures associated with unique immune responses during a subsequent infection

This study shows that host immune history from infection or vaccination influences viral mutation patterns during subsequent influenza infections, with vaccinated mice showing more mutations than preinfected-vaccinated mice.

Regulation of protein translation by TRIM21

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

Heterogeneity of Interaction Strengths and Its Consequences on Ecological Systems

The paper explores how heterogeneous interaction strengths among species can stabilize ecosystems and increase prey population density in predator-prey dynamics.

Chlamydomonas RABL4/IFT27 Mediates Phototaxis via Promoting BBSome-dependent Ciliary Export of Phospholipase D

The paper shows that IFT25/27 promotes BBSome-dependent ciliary export of PLD via controlling BBSome availability, mediating phototaxis in Chlamydomonas.

ARL3 Mediates BBSome Ciliary Turnover by Promoting Its Outward Diffusion through the Transition Zone

Total parenteral nutrition drives glucose metabolism disorders by modulating gut microbiota and its metabolites

This study shows that total parenteral nutrition (TPN) causes glucose metabolism disorders by altering gut microbiota and its metabolites, as demonstrated through human and mouse models.

Converting Muscle-mimetic Biomaterials to Cartilage-like Materials

This paper develops a protein hydrogel that mimics articular cartilage by combining physical entanglements and force-induced unfolding, achieving mechanical properties comparable to natural cartilage.

Plant Metabolic Network: A multi-species resource of plant metabolic information

The paper updates the Plant Metabolic Network (PMN) with 126 genomes and tools for analyzing metabolism across species, revealing distinct metabolic groups and demonstrating applications in drought tolerance and cell-type specific metabolism.

Effects of active dry yeast on growth performance, rumen fermentation characteristics and slaughter performance in beef cattle

This study examines how adding active dry yeast to the diet of beef cattle affects their growth, rumen fermentation, and slaughter performance, finding that 4 g/head/d improves microbial composition and carcass weight compared to low nutrition.

MondoA Drives Malignancy in cALL through Enhanced Adaptation to Metabolic Stress

This study shows MondoA promotes malignancy in pediatric cALL by enhancing metabolic stress adaptation, with potential therapeutic implications.

miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts

This study shows that miR-200 deficiency in lung cancer cells promotes metastasis by activating cancer-associated fibroblasts through Notch signaling.

Epigenetic Interaction between UTX and DNMT1 Regulates Diet-Induced Myogenic Remodeling in Brown Fat

The paper shows that the interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat by maintaining brown adipocyte identity and thermogenic function.

Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue

This study identifies NTF3 as a fat-derived neurotrophic factor that regulates sympathetic innervation and thermogenesis in adipose tissue, influencing energy metabolism and obesity.

Relationship between True Digestibility of dietary Phosphorus and Gastrointestinal Bacteria of Goats

This study examines the relationship between phosphorus digestibility and gut microbiota in goats, finding significant correlations between TDP and specific bacterial taxa in different gastrointestinal regions.

Accelerated diversification correlated with functional traits shapes extant diversity of the early divergent angiosperm family Annonaceae

This study investigates diversification patterns in Annonaceae, finding that traits like liana habit and pollinator trapping correlate with higher diversification rates, while pollen aggregation and anther septation are linked to lower rates.