Author

W. E. Louch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Biophysics· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 6 Approach:deep learning· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Assay:imaging· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2

Frequent Co-Authors

C. Smith· 3 shared E. Grandi· 3 shared H. Ni· 3 shared S. Morotti· 3 shared X. Zhang· 3 shared A. G. Edwards· 2 shared C. Soeller· 2 shared D. Sato· 2 shared

Activity by Year

2018-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersPhysiology

C. Smith

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Author profile →

8 papers

Recent·Most cited

Analysis of RyR2 distribution in HEK293 cells and mouse cardiac myocytes using 3D MINFLUX microscopy

A. H. Clowsley, A. Meletiou, R. Janicek, A. F. E. Bokhobza, E. Lucinskaite, G. Bleuer, I. Jansen, P. P. Jones, W. E. Louch, C. Soeller

This study uses 3D MINFLUX microscopy to analyze RyR2 distribution in HEK293 cells and mouse cardiac myocytes with sub-molecular resolution, revealing dense clustering and resolving discrepancies with previous methods.

Nature Communications · Dec 21, 2025Peer-reviewedPhysiology

Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling

X. Zhang, Y. Wu, C. Smith, W. E. Louch, S. Morotti, D. Dobrev, E. Grandi, H. Ni

This study uses computational models to show female atrial cardiomyocytes in AF have higher Ca2+-driven arrhythmia risk than males, with specific interventions identified to address these differences.

bioRxiv · Mar 4, 2024 · PreprintPhysiology

Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+-handling protein variation

X. Zhang, C. Smith, S. Morotti, A. G. Edwards, D. Sato, W. E. Louch, H. Ni, E. Grandi

This paper uses a 3D human atrial myocyte model to study how changes in Ca2+-handling proteins and TATS density affect arrhythmia mechanisms in disease.

bioRxiv · Jul 15, 2022Physiology

Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation

X. Zhang, H. Ni, S. Morotti, C. Smith, D. Sato, W. E. Louch, A. G. Edwards, E. Grandi

This study develops a 3D human atrial myocyte model to investigate how variations in transverse-axial tubule systems (TATS) affect Ca2+ handling and promote arrhythmia through spontaneous Ca2+ release.

bioRxiv · Jul 15, 2022Physiology

Prolonged β-Adrenergic Stimulation Disperses Ryanodine Receptor Clusters in Cardiomyocytes: Implications for Heart Failure

X. Shen, J. van den Brink, A. Bergan-Dahl, T. R. Kolstad, E. S. Norden, Y. Hou, M. Laasmaa, A. P. Quick, E. K. S. Espe, I. Sjaastad, X. Wehrens, A. Edwards, C. Soeller, W. E. Louch

This study shows prolonged β-adrenergic stimulation causes RyR cluster dispersion in cardiomyocytes, disrupting Ca2+ homeostasis and contributing to heart failure.

bioRxiv · Feb 18, 2022Cell Biology

Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks

M. Hernandez Mesa, J. van der Brink, W. E. Louch, K. McCabe, P. Rangamani

The paper uses computational modeling to show that RyR cluster geometry and phosphorylation patterns affect Ca2+ spark dynamics in heart failure.

bioRxiv · Oct 19, 2021Biophysics

A Matched-filter Based Algorithm for Subcellular Classification of T-system in Cardiac Tissues

D. F. Colli, R. Blood, A. C. Sankarankutty, F. B. Sachse, M. Frisk, W. E. Louch, P. M. Kekenes-Huskey

The paper introduces MatchedMyo, a matched-filter algorithm to classify T-system structures in cardiac tissues, revealing heterogeneous T-system remodeling in disease models.

bioRxiv · Jan 23, 2019Biophysics

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

bioRxiv · Jul 4, 2018Immunology