Author

E. Skarpen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Brech· 2 shared H. Stenmark· 2 shared A. Bellanger· 1 shared A. Jain· 1 shared A. Pfefferle· 1 shared B. Jacobs· 1 shared C. Campsteijn· 1 shared C. Grimm· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

A. Brech

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Unrestrained ESCRT-III drives chromosome fragmentation and micronuclear catastrophe

M. Vietri, S. W. Schultz, A. Bellanger, C. M. Jones, C. Raiborg, E. Skarpen, C. R. J. Pedurupillay, E. Kip, R. Timmer, A. Jain, P. Collas, R. L. Knorr, S. N. Grellscheid, H. Kusumaatmaja, A. Brech, , C. Campsteijn

This study shows that unrestrained ESCRT-III activity at micronuclei causes chromosome fragmentation and DNA damage, while it facilitates repair in primary nuclei.

bioRxiv · Jan 10, 2019Cell Biology

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

bioRxiv · Jul 4, 2018Immunology