Pro-apoptotic caspase deficiency reveals a cell-extrinsic mechanism of NK cell regulation
T. M. Olsen, W. H. Tan, A. C. Knudsen, A. Rongvaux
This study shows that caspase deficiency reduces NK cell numbers and function through a cell-extrinsic mechanism involving mitochondrial DNA leakage and type I IFN response.
bioRxiv · Sep 9, 2021 · PreprintImmunology