Author

W. J. Koch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. Gao· 3 shared A. Jungmann· 2 shared D. Kehr· 2 shared H. A. Katus· 2 shared J. Birkenstock· 2 shared J. Ritterhoff· 2 shared K. Varadi· 2 shared N. Frey· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPharmacology & Toxicology

E. Gao

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Author profile →

3 papers

Recent·Most cited

S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models

D. Kehr, J. Ritterhoff, M. Glaser, L. Jarosch, R. Salazar, K. Spaich, K. Varadi, J. Birkenstock, M. Egger, E. Gao, W. J. Koch, H. A. Katus, N. Frey, A. Jungmann, C. Busch, , P. Most

This paper develops a synthetic peptide S100A1ct that improves cardiac function and survival in heart failure models by enhancing Ca2+ cycling and targeting SERCA2a and RyR2.

bioRxiv · Mar 4, 2023Pharmacology & Toxicology

Cardiac-targeted rAAV5-S100A1 gene therapy protects against adverse remodeling and contractile dysfunction in post-ischemic hearts

D. Kehr, J. Salatzki, B. Krautz, K. Varadi, J. Birkenstock, P. Schlegel, E. Gao, W. J. Koch, J. Riffel, F. Andre, K. Peppel, H. A. Katus, N. Frey, M. Busch, H. Pfannkuche, , P. Most

This study demonstrates that cardiac-targeted rAAV5-S100A1 gene therapy reduces adverse remodeling and improves contractile function in post-ischemic hearts in pigs and mice.

bioRxiv · Mar 3, 2023 · PreprintPathology

A Peptide of the Amino-Terminus of GRK2 Induces Hypertrophy and Yet Elicits Cardioprotection after Pressure Overload

S. M. Schumacher, K. M. Bledzka, J. Grondolsky, R. Roy, E. Gao, J. K. Chuprun, W. J. Koch

This study shows that a GRK2 amino-terminal peptide induces cardiac hypertrophy but protects against heart failure during pressure overload.

bioRxiv · Jun 18, 2020Physiology