Author

W. J. O'Shaughnessy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

M. L. Reese· 4 shared A. S. Moon· 2 shared P. S. Back· 2 shared P. S. Dewangan· 2 shared D. Nicastro· 1 shared E. Reetz· 1 shared J. L. Wohlschlegel· 1 shared J. Sha· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

M. L. Reese

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery

L. Gui, W. J. O'Shaughnessy, K. Cai, E. Reetz, M. L. Reese, D. Nicastro

This study uses cryo-electron tomography to show that the apical complex in apicomplexan parasites moves as a rigid body, with the conoid structure remaining unchanged during protrusion and retraction.

bioRxiv · Apr 23, 2022 · PreprintBiophysics

Multivalent interactions drive the Toxoplasma AC9:AC10:ERK7 complex to concentrate ERK7 in the apical cap

P. S. Back, W. J. O'Shaughnessy, A. S. Moon, P. S. Dewangan, M. L. Reese, P. J. Bradley

This study identifies multivalent interactions among AC9, AC10, and ERK7 that stabilize the apical complex in Toxoplasma, concentrating ERK7 kinase activity in the apical cap.

bioRxiv · Jan 4, 2022Microbiology

Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis

P. S. Back, W. J. O'Shaughnessy, A. S. Moon, P. S. Dewangan, J. L. Wohlschlegel, J. Sha, P. Bradley, M. L. Reese

The paper identifies AC9 as an essential scaffold for ERK7 regulation during apical complex biogenesis in Toxoplasma gondii, revealing a novel inhibitory mechanism for an ancient MAPK.

Proceedings of the National Academy of Sciences · May 14, 2020Peer-reviewedMicrobiology

Loss of the conserved Alveolate kinase MAPK2 decouples Toxoplasma cell growth from the cell cycle

X. Hu, W. J. O'Shaughnessy, T. G. Beraki, M. L. Reese

This study identifies MAPK2 as essential for Toxoplasma gondii cell division by regulating centrosome duplication, leading to parasite death when MAPK2 is lost.

bioRxiv · May 13, 2020 · PreprintCell Biology