Author

P. J. Bradley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Sha· 4 shared J. A. Wohlschlegel· 3 shared A. S. Moon· 2 shared J. J. Quan· 2 shared P. S. Back· 2 shared A. C. Thind· 1 shared A. K. Snyder· 1 shared A. L. Chen· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersMicrobiology

J. Sha

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Author profile →

6 papers

Recent·Most cited

Characterization and functional analysis of Toxoplasma Golgi-associated proteins identified by proximity labelling

R. R. Pasquarelli, J. J. Quan, E. S. Cheng, V. Yang, T. A. Britton, J. Sha, J. A. Wohlschlegel, P. J. Bradley

This paper identifies and functionally analyzes novel Toxoplasma Golgi-associated proteins using proximity labeling and knockdown experiments, revealing their roles in the secretory pathway and potential as therapeutic targets.

bioRxiv · Feb 2, 2024 · PreprintMicrobiology

The Toxoplasma subpellicular network is highly interconnected and defines parasite shape for efficient motility and replication

P. S. Back, V. Senthilkumar, C. P. Choi, A. M. Ly, A. K. Snyder, J. G. Lau, G. E. Ward, P. J. Bradley

This study identifies the role of TgIMC6 in Toxoplasma's subpellicular network, showing its importance in parasite shape and function through protein interactions and morphological analysis.

bioRxiv · Aug 10, 2023 · PreprintMicrobiology

The Toxoplasma gondii effector GRA83 modulates the host's innate immune response to regulate parasite infection

A. C. Thind, C. M. Mota, A. P. N. Goncalves, J. Sha, J. A. Wohlschlegel, T. W. Mineo, P. J. Bradley

This paper identifies GRA83 as a Toxoplasma gondii effector that modulates host innate immunity, reducing parasite burden by enhancing inflammatory responses.

bioRxiv · May 31, 2023 · PreprintMicrobiology

Toxoplasma gondii encodes an array of TBC-domain containing proteins including an essential regulator that targets Rab2 in the secretory pathway

J. J. Quan, L. A. Nikolov, J. Sha, J. Wohlschlegel, P. J. Bradley

This study identifies TgTBC9 as an essential TBC-domain protein in Toxoplasma gondii that regulates Rab2 and ER-to-Golgi trafficking, offering therapeutic targets for apicomplexan parasites.

bioRxiv · May 28, 2023 · PreprintMicrobiology

Multivalent interactions drive the Toxoplasma AC9:AC10:ERK7 complex to concentrate ERK7 in the apical cap

P. S. Back, W. J. O'Shaughnessy, A. S. Moon, P. S. Dewangan, M. L. Reese, P. J. Bradley

This study identifies multivalent interactions among AC9, AC10, and ERK7 that stabilize the apical complex in Toxoplasma, concentrating ERK7 kinase activity in the apical cap.

bioRxiv · Jan 4, 2022Microbiology

A novel Toxoplasma IMC sutures-associated protein regulates suture protein targeting and colocalizes with membrane trafficking machinery

J. H. Chern, A. S. Moon, A. L. Chen, J. Sha, J. A. Wohlschlegel, P. J. Bradley

This study identifies a novel Toxoplasma gondii protein that localizes to IMC sutures, regulates suture protein targeting, and colocalizes with membrane trafficking machinery.

bioRxiv · Jun 22, 2021Microbiology