K. Cai

Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells

This study shows thyroid hormone promotes differentiation of medulloblastoma cells, reducing tumor growth by reversing EZH2-mediated repression of NeuroD1.

Atomic-level architecture of Caulobacter crescentus flagellar filaments provide evidence for multi-flagellin filament stabilization

The paper presents an atomic-level structure of Caulobacter crescentus flagellar filaments, revealing molecular interactions and glycosylation sites that contribute to multi-flagellin filament stability and motility.

PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

Evolutionary survival strategies of the female giant panda: optimizing energy resources and expenditure prior to pregnancy by postponing corpus luteum reactivation

This study investigates giant panda reproductive physiology, finding that pregnancy lasts 42 days and involves a triphasic progesterone profile with CL reactivation postponed to shorten the active luteal phase.

Sex differences in the nasal microbiome of healthy young adults

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery

This study uses cryo-electron tomography to show that the apical complex in apicomplexan parasites moves as a rigid body, with the conoid structure remaining unchanged during protrusion and retraction.

Correlative cryogenic montage electron tomography for comprehensive in-situ whole-cell structural studies

This paper introduces tools for montage electron tomography to improve imaging of large fields of view in cryo-electron tomography while maintaining high-resolution structural information.

Integration of the cyanophage-encoded phosphate binding protein into the cyanobacterial phosphate uptake system

This study shows that cyanophage PstS enhances host phosphate uptake and forms a chimeric ABC transporter with host proteins.

Structural organization of the C1b projection within the ciliary central apparatus

The paper identifies and characterizes the subunit organization of the C1b projection in the central apparatus of cilia, revealing its role in regulating dynein activity and ciliary beating.

Gut microbiome couples gut and brain during calorie restriction in treating obesity

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

A multi-omic cohort as a reference point for promoting a healthy human gut microbiome

The paper presents a large multi-omic cohort of 2,183 adults to identify correlations between gut microbiome features and various health-related factors, validated in an additional cohort.

Over 50000 metagenomically assembled draft genomes for the human oral microbiome reveal new taxa

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

Life history recorded in the vagino-cervical microbiome

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

Calorie restriction intervention induces enterotype-associated BMI loss in nonobese individuals

This study shows that calorie restriction leads to BMI loss in nonobese individuals, with variations linked to gut microbiota enterotypes.

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress

This study identifies FDX1 inhibition as a strategy to prevent proteasome inhibitor resistance in cancer by targeting mitochondrial Fe-S cluster biosynthesis.