Cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium subsp. paratuberculosis peptide vaccine.
W. C. Davis, G. M. Abdellrazeq, L. M. Fry, M. M. Elnaggar, J. P. Bannantine, D. A. Schneider, W. M. Chamberlin, A. H. A. Mahmoud, K.-T. Park, V. Hulubei
The paper shows CD4 and CD8 T-cell cognate recognition is essential for primary CTL expansion in response to a Mycobacterium avium subsp. paratuberculosis peptide vaccine in cattle.
bioRxiv · Feb 20, 2019 · PreprintImmunology