V. Hulubei

Ability of mycobacterial pathogens to establish a persistent infection is lost by deletion of a single gene, rel, regulator of the stringent response

The paper shows deletion of the rel gene in mycobacterial pathogens prevents persistent infection and impairs CD8 T cell responses in cattle, but not the timing or cytokine expression of the response.

Cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium subsp. paratuberculosis peptide vaccine.

The paper shows CD4 and CD8 T-cell cognate recognition is essential for primary CTL expansion in response to a Mycobacterium avium subsp. paratuberculosis peptide vaccine in cattle.