BiophysicsbioRxiv
Restricting α-Synuclein Transport into Mitochondria by Inhibition of α-Synuclein-VDAC Complexation as a Potential Therapeutic Target for Parkinson's Disease Treatment
M. Rajendran, M. Queralt-Martin, P. A. Gurnev…·T. K. Rostovtseva
This study shows that a peptide from hexokinase 2 inhibits alpha-synuclein-VDAC complexation, reducing alpha-synuclein mitochondrial translocation and toxicity in Parkinson's disease.
DOI 10.1007/s00018-022-04389-w