ImmunologybioRxiv
Strong basal/tonic TCR signals are associated with negative regulation of naive CD4+ T cells
W. M. Zinzow-Kramer, J. Eggert, C. D. Scharer, B. B. Au-Yeung
The paper investigates the relationship between strong tonic TCR signals and negative regulation in naive CD4+ T cells, finding that high tonic signals correlate with hypo-responsiveness and increased expression of negative regulators.
DOI 10.4049/immunohorizons.2200051