Author

C. D. Scharer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 9 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 8 Assay:bulk RNA-seq· 7 Organism:mouse· 7 Research Focus:differential expression· 6 Approach:statistical model· 6 Organism:human· 5 Research Focus:cell signaling & trafficking· 4

Frequent Co-Authors

F. E. Lund· 3 shared J. E. Bradley· 3 shared J. M. Boss· 3 shared A. K. Kania· 2 shared A. Nellore· 2 shared A. Rosenberg· 2 shared B. Mousseau· 2 shared E. Zumaquero· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

F. E. Lund

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Author profile →

10 papers

Recent·Most cited

A Multiscale Spatial Modeling Framework for the Germinal Center Response

D. P. Mu, C. D. Scharer, N. E. Kaminski, Q. Zhang

This paper develops a multiscale spatial simulation framework to model the germinal center response, recapitulating key molecular, cellular, and morphological events.

bioRxiv · Jan 26, 2024 · PreprintImmunology

Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

L. Cooper, H. Xu, J. Polmear, C. Szeto, E. S. Pang, M. Gupta, J. J. Taylor, K. J. L. Jackson, A. Nguyen, N. La Gruta, L. G. Martelotto, I. A. Parish, M. O'Keeffe, C. D. Scharer, S. Gras, K. L. Good-Jacobson

The paper identifies type I interferon dynamics as a key factor shaping memory B cell development during chronic viral infection and shows that early IFNAR-1 blockade can reverse chromatin changes.

bioRxiv · Mar 2, 2023Immunology

Memory CD4 T cell subset organization in the female reproductive tract is regulated via the menstrual cycle through CCR5 signaling

A. Swaims-Kohlmeier, A. N. Wein, F. P. Hardnett, A. N. Sheth, Z.-R. T. Li, M. E. Williams, J. Radzio-Basu, H. Zheng, C. Dinh, L. B. Haddad, E. M. Collins, J. L. Lobby, K. Kost, S. L. Hayward, I. Ofotokun, , J. Kohlmeier

bioRxiv · Oct 1, 2022 · PreprintImmunology

Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE following helminth infection

M. L. Curtiss, A. F. Rosenberg, C. D. Scharer, N. A. B. Benavides, J. E. Bradley, B. Leon, C. C. Steele, T. D. Randall, F. E. Lund

This study shows that ChI3L1 is required for TH2, TFH, and IgE responses following helminth infection and vaccination, but not for IgG1 responses.

bioRxiv · Sep 26, 2022 · PreprintImmunology

Strong basal/tonic TCR signals are associated with negative regulation of naive CD4+ T cells

W. M. Zinzow-Kramer, J. Eggert, C. D. Scharer, B. B. Au-Yeung

The paper investigates the relationship between strong tonic TCR signals and negative regulation in naive CD4+ T cells, finding that high tonic signals correlate with hypo-responsiveness and increased expression of negative regulators.

bioRxiv · Apr 20, 2022Immunology

Lactococcus lactis sb. cremoris orchestrates signal events in the gut epithelium via TLR2 to promote tissue restitution

C. R. Naudin, J. A. Owens, L. C. Askew, R. N. Khan, C. D. Scharer, J. D. Matthews, L. Luo, J. Kim, A. R. Reedy, M. E. Barbian, R. M. Jones

This study shows that Lactococcus lactis subsp. cremoris promotes gut tissue repair via TLR2 signaling, enhancing epithelial migration and cytoprotection.

bioRxiv · Dec 2, 2021 · PreprintMicrobiology

An IRF4-MYC-mTORC1 integrated pathway controls cell growth and the proliferative capacity of activated B cells during B cell differentiation in vivo

D. G. Patterson, A. K. Kania, M. J. Price, J. R. Rose, C. D. Scharer, J. M. Boss

This study identifies an IRF4-MYC-mTORC1 pathway critical for B cell proliferation and growth during differentiation, showing IRF4 regulates MYC and mTORC1 to drive metabolic reprogramming and cell cycle progression.

bioRxiv · Jun 20, 2021Immunology

Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

A. Nellore, E. Zumaquero, C. D. Scharer, R. G. King, C. M. Tipton, C. Fucile, B. Mousseau, J. E. Bradley, T. Mi, P. A. Goepfert, J. F. Kearney, J. M. Boss, T. D. Randall, I. Sanz, A. Rosenberg, F. E. Lund

The paper identifies T-bethi Bmem cells as predictors of long-lived antibody responses to influenza vaccination in humans.

bioRxiv · Feb 18, 2021 · PreprintImmunology

Conserved epigenetic programming and enhanced heme metabolism drive memory B cell reactivation

M. J. Price, C. D. Scharer, A. K. Kania, T. Randall, J. Boss

This study identifies conserved epigenetic and transcriptional signatures in memory B cells that enhance their reactivation potential, with a central role for heme metabolism.

bioRxiv · Jan 20, 2021Immunology

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

E. Zumaquero, S. L. Stone, C. D. Scharer, S. A. Jenks, A. Nellore, B. Mousseau, A. Rosal-Vela, D. Botta, J. E. Bradley, W. Wojciechowski, T. Ptacek, M. I. Danila, J. C. Edberg, S. L. Bridges, R. P. Kimberly, , F. E. Lund

This study shows IFNγ promotes T-bet expressing B cell differentiation and epigenetic reprogramming in humans, enhancing IL-21-driven antibody production.

bioRxiv · Feb 21, 2019Immunology