Z. Tao

Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis

This study shows CVB3 infection upregulates ASS1 through citrulline consumption, leading to metabolic reprogramming and macrophage inflammatory polarization, contributing to viral myocarditis.

VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300

This study identifies VGLL2 and TEAD1 fusion proteins as YAP/TAZ-independent drivers of tumorigenesis by recruiting p300 for epigenetic regulation.

A peptide derived from the SARS-CoV-2 S2-protein heptad-repeat-2 inhibits pseudoviral fusion at micromolar concentrations: Role of palmitic acid conjugation

The paper tests a palmitoylated HR2-derived peptide's ability to inhibit SARS-CoV-2 pseudoviral fusion and finds it reduces fusion activity by 76% at 10 M.

Data-driven prediction of colonization outcomes for complex microbial communities

The paper predicts colonization outcomes of exogenous microbes in complex communities using a data-driven approach, validated with synthetic data and experimental tests.

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

Enrichment and delivery of target proteins into the cell cytosol via Outer Membrane Vesicles

This study uses E. coli outer membrane vesicles to deliver target proteins into eukaryotic cells with high efficiency and enables direct labeling of proteins within vesicles.

A method for rapid nanobody screening with no bias of the library diversity

This paper introduces a method for rapid nanobody screening that preserves library diversity without subcloning or amplification bias, producing functional nanobodies against DR5 and Pfu DNA polymerase.

Pan-cancer quantification of neoantigen-mediated immunoediting in cancer evolution

This study quantifies neoantigen-mediated immunoediting stages in cancer evolution across tumor types, showing elimination and escape signals predict immunotherapy response.

Extrachromosomal DNA is associated with decreased immune cell infiltration and antigen presentation, represents a potential cancer immune evasion mechanism

This study shows that extrachromosomal DNA (ecDNA) is linked to reduced immune cell infiltration and antigen presentation, suggesting it helps cancer cells evade immune surveillance.

Fractional Laser Treatment Boosts Systemic Anti-Tumor Immunity in Combination with OX40 Agonist and PD-1 Blockade

This study shows that combining fractional laser treatment with PD-1 blockade and OX40 agonist significantly reduces tumor growth and induces complete remission in mice.

Polycomb repressive complex 2 coordinates with Sin3 histone deacetylase complex to epigenetically reprogram genome-wide expression of effectors and regulate pathogenicity in Magnaporthe oryzae

The paper shows that Polycomb repressive complex 2 and Sin3 histone deacetylase complex work together to epigenetically control effector gene expression in Magnaporthe oryzae, regulating its pathogenicity.

Personalized vagino-cervical microbiome dynamics after oral probiotics

The study tracks vagino-cervical microbiome changes in 60 women over a year after oral probiotics, finding no colonization but stability in Lactobacillus-dominated communities and potential benefits for some individuals.

An optimized 16S rRNA sequencing protocol for vaginal microbiome to avoid biased abundance estimation

The paper evaluates three 16S rRNA sequencing protocols for vaginal microbiome analysis and identifies biases in species abundance estimation, proposing an optimized protocol to improve accuracy.

Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.