ImmunologybioRxiv
RAG1 and RAG2 Non-core Regions Are Implicated in Leukemogenesis and Off-target V(D)J Recombination in BCR-ABL1-driven B-cell Lineage Lym-phoblastic Leukemia
X. Yu, W. Zhou, X. Chen…·Y. Ji
This study shows that non-core RAG regions reduce off-target V(D)J recombination and maintain genomic stability in BCR-ABL1+ B-ALL by improving RAG cleavage accuracy.
DOI 10.7554/elife.91030