W. R. Holmes

Merging of ventral fibers at adhesions drives the remodeling of cellular contractile systems in fibroblasts.

The paper identifies VSF merging as a mechanism for aligning long contractile fibers in fibroblasts, driven by mechanical forces and adhesion dynamics.

Biophysical Models of PAR Cluster Transport by Cortical Flow in C. elegans Early Embryogenesis

The paper develops a biophysical model to test how PAR-3 clusters interact with cortical flow in C. elegans embryos, showing that existing metrics like Peclet number are insufficient and proposing a new metric for distinguishing cluster-cortex interactions.

Cortical Tension Initiates the Positive Feedback Loop Between E-cadherin and F-actin

This paper presents a computational model showing cortical tension initiates a positive feedback loop between E-cadherin and F-actin, stabilizing cell-cell adhesion through mechano-chemical interactions.

Microtubules regulate pancreatic beta cell heterogeneity via spatiotemporal control of insulin secretion hot spots

This study shows microtubules regulate beta cell heterogeneity in insulin secretion by controlling secretion hot spots through spatiotemporal dynamics.

Modeling cell shape diversity arising from complex Rho GTPase dynamics

This study models how Rho GTPase dynamics generate distinct cell shapes, explaining their diversity through computational analysis of signaling mechanisms.