I. Kaverina

Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic beta cells

This study shows that glucose stimulates KIF5B-mediated microtubule sliding in pancreatic beta cells, organizing microtubule networks to support insulin secretion and prevent hypoglycemia.

CLASP2 facilitates dynamic actin filament organization along the microtubule lattice

This study shows CLASP2 crosslinks F-actin to microtubules, promoting actin filament organization along microtubule lattices and affecting cytoskeletal structure.

The microtubule minus end-binding protein CAMSAP2 does not regulate microtubule dynamics in primary pancreatic β-cells but facilitates insulin secretion

This study shows that CAMSAP2 in primary pancreatic β-cells localizes to the Golgi and supports insulin secretion by facilitating Golgi-ER trafficking, despite not regulating microtubule dynamics.

Merging of ventral fibers at adhesions drives the remodeling of cellular contractile systems in fibroblasts.

The paper identifies VSF merging as a mechanism for aligning long contractile fibers in fibroblasts, driven by mechanical forces and adhesion dynamics.

A Focal Adhesion Filament Cross-correlation Kit for fast, automated segmentation and correlation of focal adhesions and actin stress fibers in cells

This paper introduces FAFCK, a tool for automated analysis of focal adhesions and actin stress fibers, enabling correlation studies to improve mechanocellular force analysis.

Microtubules and Gαo-signaling independently regulate the preferential secretion of newly synthesized insulin granules in pancreatic islet β cells

The paper investigates how microtubules and Gαo-signaling regulate the preferential secretion of newly synthesized insulin granules in β cells, showing that their absence leads to increased secretion of older granules.

Microtubules regulate pancreatic beta cell heterogeneity via spatiotemporal control of insulin secretion hot spots

This study shows microtubules regulate beta cell heterogeneity in insulin secretion by controlling secretion hot spots through spatiotemporal dynamics.

Microtubules Regulate Spatial Localization and Availability of Insulin Granules in Pancreatic Beta Cells.

This study shows microtubules regulate insulin granule localization and PM interactions in beta cells, affecting GSIS and suggesting MT targeting as a diabetes therapy.

Activation of intracellular transport by relieving KIF1C autoinhibition

This study identifies how PTPN21 relieves KIF1C autoinhibition, enabling cargo-specific transport and bidirectional movement.