Mutations that improve the efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome
A. B. Morgenthaler, W. R. Kinney, C. C. Ebmeier, C. M. Walsh, D. J. Snyder, V. S. Cooper, W. M. Old, S. D. Copley
The paper shows that mutations improving a weak-link enzyme's efficiency are rare compared to other adaptive mutations in the genome during bacterial evolution.
bioRxiv · Apr 30, 2019Evolutionary Biology