W. S. DeWitt

A biophysical model of viral escape from polyclonal antibodies

This paper introduces a biophysical model to predict viral escape from polyclonal antibodies by analyzing how mutations affect antibody activity against specific epitopes.

Robustness of phylogenetic inference to model misspecification caused by pairwise epistasis

This study examines how Bayesian phylogenetic inference is affected by model misspecification due to pairwise epistasis and shows that tree accuracy improves with alignment size even when sites are epistatically coupled.

Joint nonparametric coalescent inference of mutation spectrum history and demography

The paper develops a method to jointly infer demographic history and mutation spectrum changes from genetic data, showing improved accuracy in reconstructing population dynamics and mutation patterns.

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

The paper analyzes TCR repertoire data to uncover associations between MHC alleles, immune exposures, and TCR sequences in a human cohort, revealing patterns linked to pathogen exposure and genetic background.