Author

P. H. Bradley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

A. N. Goga· 1 shared A. Smith· 1 shared A. Venook· 1 shared B. Edmison· 1 shared B. G. H. Guthrie· 1 shared C. Atreya· 1 shared D. Gempis· 1 shared E. L. van Blarigan· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperMicrobiology

A. N. Goga

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure-based prediction of T cell receptor:peptide-MHC interactions

This study uses AlphaFold to predict TCR:peptide-MHC interactions, showing it can accurately distinguish correct from incorrect epitopes.

bioRxiv · Aug 5, 2022Immunology

A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacy

P. Spanogiannopoulos, T. S. Kyaw, B. G. H. Guthrie, P. H. Bradley, J. V. Lee, J. Melamed, Y. N. A. Malig, K. N. Lam, D. Gempis, M. Sandy, W. Kidder, E. L. van Blarigan, C. Atreya, A. Venook, R. R. Gerona, , P. Turnbaugh

The paper shows that a conserved enzyme in gut bacteria inactivates anticancer drugs, reducing their efficacy in mice and highlighting microbial contributions to drug metabolism.

bioRxiv · May 2, 2022 · PreprintMicrobiology

Convergent clonal selection of donor- and recipient-derived CMV-specific T cells in hematopoietic stem cell transplant patients

J. R. Erickson, T. Stevens-Ayers, F. Mair, B. Edmison, M. Boeckh, P. H. Bradley, M. Prlic

The paper tracks T cell competition in CMV-reactivation post-transplant, finding donor-derived T cells expand but recipient-derived memory T cells remain dominant due to convergent clonal selection.

bioRxiv · Sep 14, 2021Immunology

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

W. S. DeWitt, A. Smith, G. Schoch, J. A. Hansen, F. A. Matsen, P. H. Bradley

The paper analyzes TCR repertoire data to uncover associations between MHC alleles, immune exposures, and TCR sequences in a human cohort, revealing patterns linked to pathogen exposure and genetic background.

bioRxiv · May 2, 2018Immunology