Author

C. E. Radford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

J. D. Bloom· 4 shared T. C. Yu· 3 shared B. Dadonaite· 2 shared K. H. Crawford· 2 shared A. G. Farrell· 1 shared A. S. Dingens· 1 shared B. B. Larsen· 1 shared D. D. Ho· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersEvolutionary Biology

J. D. Bloom

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Author profile →

4 papers

Recent·Most cited

Functional and antigenic landscape of the Nipah virus receptor binding protein

B. B. Larsen, T. McMahon, J. T. Brown, Z. Wang, C. E. Radford, J. E. Crowe, D. Veesler, J. D. Bloom

This study uses deep mutational scanning to analyze how mutations in the Nipah virus receptor-binding protein affect function, receptor binding, and antibody escape, revealing constrained regions and limited antigenic variation in natural strains.

Cell · May 1, 2025Peer-reviewedEvolutionary Biology

Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning

C. E. Radford, P. Schommers, L. Gieselmann, K. H. Crawford, B. Dadonaite, T. C. Yu, A. S. Dingens, J. Overbaugh, F. Klein, J. D. Bloom

This study maps the neutralizing specificity of human anti-HIV serum using deep mutational scanning to identify Env mutations affecting neutralization by polyclonal sera.

bioRxiv · Mar 23, 2023Immunology

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike

B. Dadonaite, K. H. Crawford, C. E. Radford, A. G. Farrell, T. C. Yu, W. W. Hannon, P. Zhou, R. Andrabi, D. R. Burton, L. Liu, D. D. Ho, R. A. Neher, J. D. Bloom

This paper introduces a pseudovirus system for deep mutational scanning of SARS-CoV-2 spike protein mutations, showing how they affect antibody neutralization and infection.

bioRxiv · Oct 13, 2022Microbiology

A biophysical model of viral escape from polyclonal antibodies

T. C. Yu, Z. T. Thornton, W. H. Hannon, W. S. DeWitt, C. E. Radford, F. A. Matsen, J. D. Bloom

This paper introduces a biophysical model to predict viral escape from polyclonal antibodies by analyzing how mutations affect antibody activity against specific epitopes.

bioRxiv · Sep 17, 2022Evolutionary Biology