T. C. Yu

Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin

The paper maps how HA mutations affect neutralization by serum from different age groups, showing age-dependent antigenic effects and implications for viral evolution.

Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning

This study maps the neutralizing specificity of human anti-HIV serum using deep mutational scanning to identify Env mutations affecting neutralization by polyclonal sera.

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike

This paper introduces a pseudovirus system for deep mutational scanning of SARS-CoV-2 spike protein mutations, showing how they affect antibody neutralization and infection.

A biophysical model of viral escape from polyclonal antibodies

This paper introduces a biophysical model to predict viral escape from polyclonal antibodies by analyzing how mutations affect antibody activity against specific epitopes.