The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues
M. Spoerrer, D. Kah, R. C. Gerum, B. Reischl, D. Huraskin, C. A. Dessalles, W. Schneider, W. H. Goldmann, H. Herrmann, I. Thievessen, C. S. Clemen, O. Friedrich, S. Hashemolhosseini, R. Schroeder, B. Fabry
This study shows that the desmin mutation R349P increases contractility and fragility of muscle micro-tissues generated from stem cells, leading to rapid disintegration and mechanical rupture.
bioRxiv · Jul 23, 2021Biophysics