PI3Kβ inhibition restores ALK inhibitor sensitivity in ALK-rearranged lung cancer
K. Wennerberg, E. W. Verschuren, S. Talwelkar, M. I. Mäyränpää, J. Schüler, N. Linnavirta, A. Hemmes, S. Adinolfi, M. Kankainen, W. Sommergruber, A.-L. Levonen, J. Räsänen, A. Knuuttila
The paper identifies PI3Kβ as a mediator of resistance to ALK inhibitors in ALK-rearranged lung cancer and shows that combining ALK and PI3Kβ inhibitors overcomes resistance.
bioRxiv · Mar 18, 2021 · PreprintCancer Biology