Author

S. Adinolfi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A.-L. Levonen· 2 shared A. Hemmes· 1 shared A. J. Deen· 1 shared A. Knuuttila· 1 shared A. Pastore· 1 shared A. Poso· 1 shared C. Iannuzzi· 1 shared D. Svergun· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

A.-L. Levonen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

A. J. Deen, S. Adinolfi, J. Harkonen, T. Patinen, X. Liu, T. Laitinen, P. Takabe, K. Kainulainen, S. Pasonen-Seppanen, L. Gawriyski, U. Thanigai Arasu, I. Selvarajan, P. Makinen, H. Laitinen, E. Kansanen, , A.-L. Levonen

This study shows that KEAP1 mutations in lung cancer activate TRAF2-NFκB signaling, enhancing cell survival by preventing apoptosis.

bioRxiv · Oct 10, 2023Cancer Biology

PI3Kβ inhibition restores ALK inhibitor sensitivity in ALK-rearranged lung cancer

K. Wennerberg, E. W. Verschuren, S. Talwelkar, M. I. Mäyränpää, J. Schüler, N. Linnavirta, A. Hemmes, S. Adinolfi, M. Kankainen, W. Sommergruber, A.-L. Levonen, J. Räsänen, A. Knuuttila

The paper identifies PI3Kβ as a mediator of resistance to ALK inhibitors in ALK-rearranged lung cancer and shows that combining ALK and PI3Kβ inhibitors overcomes resistance.

bioRxiv · Mar 18, 2021 · PreprintCancer Biology

Molecular mechanism of the dual regulation of bacterial iron sulfur cluster biogenesis by CyaY and IscX

A. Pastore, S. Adinolfi, R. Puglisi, J. Crack, C. Iannuzzi, F. Dal Piaz, P. Konarev, D. Svergun, S. Martin, N. Le Brun

The paper investigates the interaction between IscX and CyaY in bacterial iron-sulfur cluster assembly, showing IscX modulates CyaY's inhibitory effect on cluster formation.

bioRxiv · Nov 3, 2017Biophysics