Cancer BiologybioRxivPreprint
Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway
S. F. Plugge, H. Ma, J. Y. van der Vaart…·M. M. Maurice
This study shows that LKB1 loss in intestinal cells leads to a pre-malignant state linked to serrated colorectal cancer, which is amplified by loss-of-heterozygosity.