Author

M. M. Maurice

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2

Frequent Co-Authors

I. Jordens· 4 shared J. M. Bugter· 4 shared A. Merenda· 2 shared B.-K. Koo· 2 shared C. Jamieson· 2 shared E. Janssen· 2 shared J. Sprangers· 2 shared M. Vermeulen· 2 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCell Biology

I. Jordens

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled family members

J. M. Bugter, P. van Kerkhof, E. Janssen, T. Tran Ngoc Minh, D. Iglesias van Montfort, C. Jamieson, I. Jordens, M. M. Maurice

This study shows RNF43 and ZNRF3 differentially regulate endocytosis of specific Frizzled family members through their transmembrane domains, linking these differences to cancer mutation patterns.

bioRxiv · Nov 23, 2023 · PreprintCell Biology

Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway

S. F. Plugge, H. Ma, J. Y. van der Vaart, J. Sprangers, F. H. M. Morsink, D. Xanthakis, C. Jamieson, K. B. W. Stroot, A. R. Keijzer, T. Margaritis, T. Candelli, R. Straver, J. de Ridder, F. C. P. Holstege, W. W. J. de Leng, , M. M. Maurice

This study shows that LKB1 loss in intestinal cells leads to a pre-malignant state linked to serrated colorectal cancer, which is amplified by loss-of-heterozygosity.

bioRxiv · Jul 17, 2023 · PreprintCancer Biology

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance

F. van der Krift, D. W. Zijlmans, R. Shukla, A. Javed, P. I. Koukos, L. L. E. Schwarz, E. P. M. Timmermans-Sprang, P. E. M. Maas, D. Gahtory, M. van den Nieuwboer, J. A. Mol, G. J. Strous, A. M. J. J. Bonvin, E. J. A. Veldhuizen, M. van der Stelt, , M. M. Maurice

This study identifies a novel antifolate, C1, that overcomes methotrexate resistance by targeting FPGS-deficient cells through DHFR inhibition.

bioRxiv · Feb 26, 2023Biochemistry

Stabilisation of β-Catenin-WNT signalling by USP10 in APC-truncated colorectal cancer drives cancer stemness and enables super-competitor signalling

M. Reissland, O. Hartmann, S. Tauch, C. Prieto-Garcia, C. Schulte, D. Solvie, S. Loebbert, A. C. Jacomin, M. Pesic, J. M. Bugter, C. Schuelein-Voelk, C. Fuss, N. Pahor, C. Ade, V. Buck, , M. E. Diefenbacher

This study identifies USP10 as a deubiquitylase that stabilizes β-Catenin in APC-truncated colorectal cancer, enhancing WNT signaling and cancer stemness.

bioRxiv · Feb 10, 2023 · PreprintCancer Biology

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

G. Colozza, H. Lee, A. Merenda, S.-H. Wu, A. Catala-Bordes, T. Radaszkiewicz, I. Jordens, J.-H. Lee, A.-D. Bamford, F. Farnhammer, T. Y. Low, M. M. Maurice, V. Bryja, J. Kim, B.-K. Koo

This study identifies Daam1/2 as a regulator of Wnt signaling that is essential for Paneth cell differentiation and intestinal stem cell homeostasis.

bioRxiv · Jan 24, 2023Cell Biology

Mutation-induced phenotypic plasticity drives formation of a pro-metastatic tumour-intrinsic niche

J. M. Bugter, L. El Bouazzaoui, E. Kucukkose, M. L. Mills, Y. Hong, J. Sprangers, I. Jordens, D. Kokkinidi, S. Plugge, A. Venhuizen, S. Bosman, J. Hageman, N. Fenderico, K. Gilroy, D. Montiel Gonzalez, , M. M. Maurice

This study identifies mutation-induced phenotypic plasticity as a driver of a pro-metastatic tumour-intrinsic niche in BRAF-mutant colorectal cancer.

bioRxiv · Dec 22, 2022 · PreprintCancer Biology

RNF43 truncating mutations mediate a tumour suppressor-to-oncogene switch to drive niche-independent self-renewal in cancer

M. Spit, N. Fenderico, I. Jordens, T. Radaszkiewicz, R. G. H. Lindeboom, J. M. Bugter, L. Ootes, M. van Osch, E. Janssen, K. E. Boonekamp, K. Hanakova, D. Potesil, Z. Zdrahal, S. F. Boj, J. P. Medema, , M. M. Maurice

This study identifies RNF43 truncating mutations that switch from tumor suppressor to oncogene, enabling niche-independent self-renewal in cancer and resistance to anti-Wnt therapy.

bioRxiv · Sep 1, 2019Cancer Biology