Author

F. C. P. Holstege

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

J. J. Molenaar· 3 shared M. M. Van Noesel· 3 shared P. Kemmeren· 3 shared T. Margaritis· 3 shared A. Janse· 2 shared B. B. J. Tops· 2 shared H. H. D. Kerstens· 2 shared J. Anderson· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

J. J. Molenaar

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors

I. A. E. M. van Belzen, M. C. van Tuil, S. Badloe, A. Janse, E. T. P. Verwiel, M. Santoso, S. de Vos, J. Baker-Hernandez, H. H. D. Kerstens, N. Solleveld-Westerink, M. T. Meister, J. Drost, M. M. van den Heuvel-Eibrink, J. H. M. Merks, J. J. Molenaar, , J. Y. Hehir-Kwa

The paper identifies prevalent and pathogenic complex structural variations in pediatric solid tumors, linking them to adverse clinical outcomes and potential therapeutic targets.

bioRxiv · Sep 19, 2023Cancer Biology

Intestinal LKB1 loss drives a pre-malignant program along the serrated cancer pathway

S. F. Plugge, H. Ma, J. Y. van der Vaart, J. Sprangers, F. H. M. Morsink, D. Xanthakis, C. Jamieson, K. B. W. Stroot, A. R. Keijzer, T. Margaritis, T. Candelli, R. Straver, J. de Ridder, F. C. P. Holstege, W. W. J. de Leng, , M. M. Maurice

This study shows that LKB1 loss in intestinal cells leads to a pre-malignant state linked to serrated colorectal cancer, which is amplified by loss-of-heterozygosity.

bioRxiv · Jul 17, 2023 · PreprintCancer Biology

Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

J. Wienke, L. L. Visser, W. M. Kholosy, K. M. Keller, M. Barisa, S. Munnings-Tomes, E. Carlton, E. Poon, A. Rodriguez, R. Bernardi, F. Van den Ham, S. R. Van Hooff, Y. A. H. Matser, M. Tas, K. P. S. Langenberg, , J. J Molenaar

The paper uses single-cell RNA sequencing to analyze neuroblastoma and identifies the NECTIN2-TIGIT axis as a potential target for immunotherapy.

bioRxiv · Jul 15, 2022Cancer Biology

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

M. T. Meister, M. J. A. Groot Koerkamp, T. de Souza, W. B. Breunis, E. Frazer-Mendelewska, M. Brok, J. DeMartino, F. Manders, C. Calandrini, H. H. D. Kerstens, A. Janse, M. E. M. Dolman, S. Eising, K. P. S. Langenberg, M. van Tuil, , F. C. P. Holstege

This study generates tumor organoid models of rhabdomyosarcoma subtypes that closely resemble original tumors and can be used for drug screening and genetic modification.

bioRxiv · Jan 3, 2022Cancer Biology

Acyl chain shortening induced by inhibition of acetyl-CoA carboxylase renders phosphatidylcholine redundant

X. Bao, M. C. Koorengevel, M. J. A. Groot Koerkamp, A. Homavar, A. Weijn, S. Crielaard, M. F. Renne, W. J. C. Geerts, M. A. Surma, M. Mari, F. C. P. Holstege, C. Klose, A. I. P. M. de Kroon

This study shows that acyl chain shortening via ACC1 inhibition allows yeast to grow without phosphatidylcholine by altering lipid biosynthesis pathways.

bioRxiv · Feb 8, 2021Biochemistry

A comprehensive map of genetic interactions in childhood cancer reveals multiple underlying biological mechanisms

J. T. Daub, S. Amini, D. J. E. Kersjes, X. Ma, N. Jäger, J. Zang, S. M. Pfister, F. C. P. Holstege, P. Kemmeren

The paper identifies genetic interactions in childhood cancers using a statistical pipeline, revealing 15 co-occurring and 27 mutually exclusive gene pairs, with most mechanisms linked to tumor subtypes or pathways.

bioRxiv · Nov 17, 2020Cancer Biology

Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

G. Kildisiute, W. M. Kholosy, M. D. Young, K. Roberts, R. Elmentaite, S. R. van Hooff, E. Khabirova, A. Piapi, C. Thevanesan, E. Bugallo Blanco, C. Burke, L. Mamanova, P. Lijnzaad, T. Margaritis, F. C. P. Holstege, , S. Behjati

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

bioRxiv · Jun 22, 2020Cancer Biology