IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation
E. Zumaquero, S. L. Stone, C. D. Scharer, S. A. Jenks, A. Nellore, B. Mousseau, A. Rosal-Vela, D. Botta, J. E. Bradley, W. Wojciechowski, T. Ptacek, M. I. Danila, J. C. Edberg, S. L. Bridges, R. P. Kimberly, , F. E. Lund
This study shows IFNγ promotes T-bet expressing B cell differentiation and epigenetic reprogramming in humans, enhancing IL-21-driven antibody production.
bioRxiv · Feb 21, 2019Immunology