Author

J. E. Bradley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Ecology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 7 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Research Focus:differential expression· 3 Approach:statistical model· 3 Organism:human· 2

Frequent Co-Authors

F. E. Lund· 4 shared T. D. Randall· 4 shared B. Mousseau· 3 shared C. D. Scharer· 3 shared C. H. Taylor· 3 shared E. Zumaquero· 3 shared I. M. Friberg· 3 shared J. A. Jackson· 3 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersImmunology

F. E. Lund

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context

I. Mair, J. Fenn, A. Wolfenden, A. Lowe, A. Bennett, A. Muir, J. Thompson, O. Dieumerci, L. Logunova, S. Shultz, K. J. Else, J. E. Bradley

The paper compares immune responses to Trichuris muris in wild and laboratory mice, finding quantitative differences and age-specific effects in cytokine production and Th1/Th2 balance.

bioRxiv · Aug 28, 2023 · PreprintImmunology

Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection and reproduction in a wild rodent

K. M. Wanelik, M. Begon, J. E. Bradley, I. M. Friberg, J. A. Jackson, C. H. Taylor, S. Paterson

This study identifies a sex-dependent polymorphism in the IgE receptor affecting immune gene expression, infection susceptibility, and reproductive success in wild field voles.

bioRxiv · Nov 7, 2022Ecology

Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE following helminth infection

M. L. Curtiss, A. F. Rosenberg, C. D. Scharer, N. A. B. Benavides, J. E. Bradley, B. Leon, C. C. Steele, T. D. Randall, F. E. Lund

This study shows that ChI3L1 is required for TH2, TFH, and IgE responses following helminth infection and vaccination, but not for IgG1 responses.

bioRxiv · Sep 26, 2022 · PreprintImmunology

Early-life immune expression profiles predict later life health and fitness in a wild rodent

K. M. Wanelik, M. Begon, J. E. Bradley, I. M. Friberg, C. H. Taylor, J. A. Jackson, S. Paterson

The paper examines how early-life immune gene expression profiles in voles predict later life health and fitness outcomes, including reproductive success and infection susceptibility.

bioRxiv · Oct 8, 2021Ecology

ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells

V. Panneton, B. C. Mindt, Y. Bouklouch, A. Bouchard, S. Mohammaei, J. Chang, M. Witalis, J. Li, A. Stancescu, J. E. Bradley, T. D. Randall, J. H. Fritz, W.-K. Suh

This study shows ICOS costimulation is essential for Tfr cell differentiation during GC reactions and highlights their role in immune tolerance.

bioRxiv · Sep 14, 2021Immunology

Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

A. Nellore, E. Zumaquero, C. D. Scharer, R. G. King, C. M. Tipton, C. Fucile, B. Mousseau, J. E. Bradley, T. Mi, P. A. Goepfert, J. F. Kearney, J. M. Boss, T. D. Randall, I. Sanz, A. Rosenberg, F. E. Lund

The paper identifies T-bethi Bmem cells as predictors of long-lived antibody responses to influenza vaccination in humans.

bioRxiv · Feb 18, 2021 · PreprintImmunology

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

R. G. King, A. Silva-Sanchez, J. N. Peel, D. Botta, S. Meza-Perez, R. Allie, M. D. Schultz, M. Liu, J. E. Bradley, S. Qiu, G. Yang, F. Zhou, E. Zumaquero, T. S. Simpler, B. Mousseau, , S. Roberts

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

bioRxiv · Oct 10, 2020 · PreprintImmunology

Decomposing variation in immune response in a wild rodent population

K. M. Wanelik, M. Begon, E. Arriero, J. E. Bradley, I. M. Friberg, J. A. Jackson, C. H. Taylor, S. Paterson

The paper identifies three categories of immune response variation in field voles and finds markers with strong individual variation across these categories.

bioRxiv · Apr 29, 2019Ecology

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

E. Zumaquero, S. L. Stone, C. D. Scharer, S. A. Jenks, A. Nellore, B. Mousseau, A. Rosal-Vela, D. Botta, J. E. Bradley, W. Wojciechowski, T. Ptacek, M. I. Danila, J. C. Edberg, S. L. Bridges, R. P. Kimberly, , F. E. Lund

This study shows IFNγ promotes T-bet expressing B cell differentiation and epigenetic reprogramming in humans, enhancing IL-21-driven antibody production.

bioRxiv · Feb 21, 2019Immunology