Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its pathological conformational conversion
L.-Q. Wang, Y. Ma, H.-Y. Yuan, K. Zhao, M.-Y. Zhang, Q. Wang, X. Huang, W.-C. Xu, J. Chen, D. Li, D. Zhang, L. Zou, P. Yin, C. Liu, Y. Liang
The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.
bioRxiv · Dec 7, 2021Biochemistry