P. Yin

Cryosectioning-enhanced super-resolution microscopy for single-protein imaging across cells and tissues

The paper introduces tkPAINT, a method combining TIRF microscopy and Tokuyasu cryosectioning to enhance DNA-PAINT for single-protein imaging and molecular counting with 3 nm precision across cells and tissues.

Deciphering the molecular mechanism underlying morphology transition in two-component DNA-protein cophase separation

The paper investigates DNA-protein co-condensates, identifying two morphology transitions and growth dynamics governed by DNA-p53 interaction strength.

Forsythoside A blocks the infection of Avian Infectious Bronchitis Virus through binding S1 subunit

This study shows Forsythoside A inhibits Avian Infectious Bronchitis Virus by binding to its S1 subunit, preventing viral attachment and infection.

A Stapled Peptide Inhibitor of METTL3-METTL14 for Cancer Therapy

This paper develops a stapled peptide inhibitor of METTL3-METTL14 that suppresses tumor growth by inhibiting m6A methylation and promoting METTL3 degradation.

Efficient algorithms for designing maximally sized orthogonal DNA sequence libraries

The paper introduces SeqWalk, an efficient algorithm for designing large orthogonal DNA sequence libraries by minimizing sequence symmetry in a de Bruijn graph representation.

Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its pathological conformational conversion

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

Sub-3 Angstrom cryo-EM structure of RNA enabled by engineered homomeric self-assembly

This paper introduces a method to improve cryo-EM analysis of RNA structures by engineering kissing-loop sequences for homomeric assembly, achieving high-resolution reconstructions of RNA molecules.

Familial prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

A DNA nanoscope that identifies and precisely localizes over a hundred unique molecular features with nanometer accuracy

The paper introduces a DNA nanoscope that spatially maps and uniquely identifies over 100 molecular features with nanometer accuracy using DNA barcoding and sequencing.

Multiplexed in situ protein imaging using DNA-barcoded antibodies withextended hybridization chain reactions

This paper introduces a DNA-based method to enhance multiplexed protein imaging using primary antibodies, demonstrating its application in cultured cells and mouse retina sections.

Cryo-EM Structure of the Human Mitochondrial Translocase TIM22 Complex

The paper reports the cryo-EM structure of the human TIM22 complex at 3.7 angstrom resolution, revealing its architecture and potential mechanism for protein import.

Three dimensional nanoscopy of whole cells and tissues with in situ point spread function retrieval

This paper introduces a method to achieve high-precision 3D nanoscopy across whole cells and tissues by retrieving the in situ point spread function from single-molecule data.

Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER

This paper introduces Immuno-SABER, a method for highly multiplexed protein imaging that overcomes limitations in sensitivity and throughput.

Rapid Sequential In Situ Multiplexing With DNA-Exchange-Imaging

This paper introduces DNA-Exchange-Imaging, a method for rapid, highly multiplexed in situ protein visualization, achieving sub-20 nm resolution and reducing imaging time from days to minutes.