L. Zou

ALS-causing SOD1 mutations H46R and G85R form similar novel amyloid fibril structures and promote ferroptosis in cells

This study shows that two ALS-causing SOD1 mutations form similar amyloid fibrils that promote ferroptosis in neuronal cells.

The YTHDF1-3 proteins are bidirectionally influenced by the codon content of their mRNA targets

This study identifies that YTHDF1-3 proteins modulate mRNA translation and stability based on codon content, revealing bidirectional regulation of mRNA fate.

Identification and characterization of a beta-1,4 Galactosidase from Elizabethkingia meningoseptica and its application on living cell surface

This study identifies and characterizes a beta-1,4 galactosidase from Elizabethkingia meningoseptica that can remove galactose from living cell surfaces, named geGalaseI.

Quantitative Learning of Cellular Features From Single-cell Transcriptomics Data Facilitates Effective Drug Repurposing

This study introduces SuperFeat, a framework that uses single-cell transcriptomics data to identify drug targets by modeling adverse cellular states, validated in vitro and in vivo.

CryoEM architecture of a native stretch-sensitive membrane microdomain

This study determines the cryo-EM structure of native yeast eisosomes, revealing lipid organization and dynamic stretching mechanisms in membrane microdomains.

CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer

This study uses CRISPR screens to identify genetic factors affecting PARP inhibitor sensitivity and resistance in prostate cancer, revealing novel targets and mechanisms.

A full spectrum PNGase activity analysis of R328 mutations on NGLY1

This study evaluates the impact of R328 mutations on NGLY1 activity using an in vitro assay, identifying dysfunctional, similar, and decreased activity mutations.

Single cell Transcriptome and T cell Repertoire Mapping of the Mechanistic Signatures and T cell Trajectories Contributing to Vascular and Dermal Manifestations of Behcet Disease

This study maps single-cell transcriptomes and T cell repertoires in Behcet's disease to identify immune mechanisms and T cell trajectories in vascular and dermal manifestations.

The SARS-CoV-2 protein NSP2 impairs the microRNA-induced silencing capacity of human cells

This study identifies NSP2 as a SARS-CoV-2 protein that disrupts microRNA-mediated gene silencing by interacting with the 4EHP-GIGYF2 complex.

Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its pathological conformational conversion

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of Elizabethkingia spp.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer

This study shows that APOBEC3A mutagenesis driven by targeted therapies promotes drug resistance in non-small cell lung cancer.

Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition

This study shows that leukemia cell of origin affects apoptotic priming and sensitivity to LSD1 inhibitors, with Evi1 modulating p53 stability and activity.

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives

The paper identifies food and drug additives that inhibit intestinal drug transporters and shows gut bacteria can inactivate these additives, reducing their inhibitory effect.

Crif1 Promotes Osteoporosis in Mice after Radiation

This study shows that Crif1 promotes radiation-induced osteoporosis in mice by increasing RANKL expression and that targeting Crif1 could be a therapeutic strategy.

Co-regulation and functional cooperativity of FOXM1 and RHNO1 bidirectional genes in ovarian cancer

This study identifies functional cooperativity between FOXM1 and RHNO1 bidirectional genes in ovarian cancer and suggests combinatorial targeting as a therapeutic strategy.

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies

The paper identifies SLC22A24 as a transporter for steroid conjugates and bile acids, linking genetic variants to steroid levels and disease.

TMC1 confers a leak conductance to modulate excitability of auditory hair cells in mammals

This study identifies TMC1 as providing a background leak conductance in mouse auditory hair cells, essential for action potential firing and tonotopic organization.

Dietary lysozyme supplement alters serum biochemical makers and milk metabolite profile of sows via gut microbiota

This study shows that lysozyme supplementation in sows reduces gut microbial diversity, alters serum immunity, and changes breast milk metabolites through gut microbiota modulation.

Molecular evolution, diversity and adaptation of H7N9 influenza A viruses in China

The paper analyzes the evolution and adaptation of H7N9 influenza viruses in China, identifying lineage-specific mutations and high-pathogenicity strains.