Author

H.-Y. Yuan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. Liu· 3 shared D. Li· 3 shared K. Zhao· 3 shared L.-Q. Wang· 3 shared Y. Liang· 3 shared Y. Ma· 3 shared D. Zhang· 2 shared J. Chen· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

C. Liu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ALS-causing SOD1 mutations H46R and G85R form similar novel amyloid fibril structures and promote ferroptosis in cells

L.-Q. Wang, Y. Ma, M.-Y. Zhang, H.-Y. Yuan, X.-N. Li, K. Zhao, W. Xia, X. Huang, J. Chen, L. Zou, D. Li, Z. Wang, W. Le, C. Liu, Y. Liang

This study shows that two ALS-causing SOD1 mutations form similar amyloid fibrils that promote ferroptosis in neuronal cells.

Science Advances · Nov 1, 2024Peer-reviewedBiochemistry

Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its pathological conformational conversion

L.-Q. Wang, Y. Ma, H.-Y. Yuan, K. Zhao, M.-Y. Zhang, Q. Wang, X. Huang, W.-C. Xu, J. Chen, D. Li, D. Zhang, L. Zou, P. Yin, C. Liu, Y. Liang

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

bioRxiv · Dec 7, 2021Biochemistry

Familial prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

L.-Q. Wang, K. Zhao, H.-Y. Yuan, X.-N. Li, H.-B. Dang, Y. Ma, Q. Wang, C. Wang, Y. Sun, J. Chen, D. Li, D. Zhang, P. Yin, C. Liu, Y. Liang

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

bioRxiv · Feb 18, 2021Biochemistry

Stabilizing selection of seasonal influenza receptor binding in populations with partial immunity

J. A. Hay, A. Junus, S. Riley, H.-Y. Yuan

This study shows stabilizing selection on influenza HA receptor binding in populations with partial immunity, due to competing within- and between-host selective pressures.

bioRxiv · Jun 27, 2020 · PreprintEvolutionary Biology

The effects of seasonal climate variability on dengueannual incidence in Hong Kong: A modellingstudy

H.-Y. Yuan, J. Liang, P.-S. Lin, K. Sucipto, M. M. Tsegaye, T.-H. Wen, S. Pfeiffer, D. P. Pfeiffer

This study models the relationship between seasonal climate variability and dengue incidence in Hong Kong, finding that pre-summer rainfall negatively correlates with annual incidence while temperature positively correlates.

bioRxiv · Jan 20, 2020Ecology