Manipulation of Bacterial ROS Production Leads to Self-escalating DNA Damage and Resistance-resistant Lethality for Intracellular Mycobacteria
J. Song, M. Wang, H. Tao, A. Yang, Z. Zhu, S. Bai, M. Luo, J. Xu, X. Liu, Y. Sun, P. Hu, W.-L. Wong, F. Li, Y. Chen, Q. Cai, , X. Feng
This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.
bioRxiv · Jul 7, 2023 · PreprintMicrobiology