Exifone is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration
D. Patnaik, P.-C. Pao, W.-N. Zhao, M. C. Silva, N. K. Hylton, P. S. Chindavong, L. Pan, L.-H. Tsai, S. J. Haggarty
This paper identifies exifone as a potent HDAC1 activator that provides neuroprotection in human neuronal models of neurodegeneration by enhancing deacetylase activity and reducing histone acetylation.
bioRxiv · Mar 2, 2020Biochemistry