Author

L.-H. Tsai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

A. Sheen· 1 shared A. T. Wassie· 1 shared A. Tabet· 1 shared A.-H. Tang· 1 shared C. Apra· 1 shared D. J. Irvine· 1 shared D. Patnaik· 1 shared D. Sarkar· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBioengineering

A. Sheen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Reprogramming brain immunosurveillance with engineered cytokines

A. Tabet, Y. Agarwal, J. Stinson, C. Apra, V. Will, M. Manthey, N. Momin, A. Sheen, M. Murdock, L. Santollani, L.-H. Tsai, I. Chiu, S. E. Lawler, D. J. Irvine, K. D. Wittrup, P. Anikeeva

This study shows engineered cytokines can reprogram brain immunosurveillance by extending their residence time in the brain using alum scaffolds, delaying tumor progression in mouse models.

bioRxiv · Jun 21, 2022 · PreprintBioengineering

Expansion Revealing: Decrowding Proteins to Unmask Invisible Brain Nanostructures

D. Sarkar, J. Kang, A. T. Wassie, M. E. Schroeder, Z. Peng, T. B. Tarr, A.-H. Tang, E. Niederst, J. Z. Young, L.-H. Tsai, T. A. Blanpied, E. S. Boyden

Expansion Revealing decrowds proteins to reveal previously invisible nanostructures in brain tissue, including presynaptic calcium channel alignment and amyloid nanoclusters in Alzheimer's models.

bioRxiv · Aug 29, 2020 · PreprintBioengineering

Exifone is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

D. Patnaik, P.-C. Pao, W.-N. Zhao, M. C. Silva, N. K. Hylton, P. S. Chindavong, L. Pan, L.-H. Tsai, S. J. Haggarty

This paper identifies exifone as a potent HDAC1 activator that provides neuroprotection in human neuronal models of neurodegeneration by enhancing deacetylase activity and reducing histone acetylation.

bioRxiv · Mar 2, 2020Biochemistry