W.-T. Chu

Uncovering the lung cancer mechanisms through the chromosome structural ensemble characteristics

This study develops a chromosome dynamic structural model to analyze the structural ensemble characteristics of normal and lung cancer cells, revealing links between chromosome structure, epigenetics, and gene expression.

Modulating the activities of chloroplasts and mitochondria promotes ATP production and plant growth

This study shows that overexpressing purple acid phosphatase 2 in chloroplasts and mitochondria improves ATP production, plant growth, and seed yield by balancing reducing equivalents and enhancing photosynthesis.

Investigations of the Underlying Mechanisms of HIF-1α and CITED2 Binding to TAZ1

This study investigates the competition mechanisms between HIF-1 and CITED2 binding to TAZ1 using structure-based models and simulations.