Intratumoral Resident Microbes Directly Participate in Resistance to EGFR-TKI Targeted Drug Therapy through Metabolism in NSCLC
Huan Wang, Jiarui Zhang, Jiaxun Zhang, Wang Hou, Jing Zhou, Maolin Li, Xuyan Liu, Yangqian Li, Fei Fu, Panwen Tian, Weimin Li, Dan Liu, Dan Xie
This study shows that tumor-resident microbes like Bacillus mycoides and Pseudomonas veronii metabolize EGFR-TKIs, reducing their efficacy in NSCLC.
bioRxiv · Mar 12, 2025 · PreprintMicrobiology