Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells
Bin Sun, Jing Guo, Dong Yang…·Xudong Zhao
This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.
Author
Sichuan UniversityORCID 0000-0001-6791-1704Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Bin Sun, Jing Guo, Dong Yang…·Xudong Zhao
This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.
Cheng Cheng, Yangqian Li, Suyan Wang…·Weimin Li
This study characterizes the lung microbiome in health and respiratory diseases using metagenomic sequencing, identifying key species and functional pathways associated with different conditions.
Huan Wang, Jiarui Zhang, Jiaxun Zhang…·Dan Xie
This study shows that tumor-resident microbes like Bacillus mycoides and Pseudomonas veronii metabolize EGFR-TKIs, reducing their efficacy in NSCLC.
Zhenhua Zhou, Qiao Weng, Dan Liu…·Yali Hu
The paper identifies eNK cells as key regulators of endometrial homeostasis, showing their role in preventing fibrosis and demonstrating their therapeutic potential in intrauterine adhesions.
Xuan He, Jiajing Jiang, Guo Li…·Weimin Li
This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.
Yaohua Yang, Yaxin Chen, Shuai Xu…·Jirong Long
The paper identifies tissue-specific DNA methylation biomarkers for cancer risk by integrating genome and epigenome data from the GTEx consortium and GWAS data.