Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells
Bin Sun, Jing Guo, Dong Yang…·Xudong Zhao
This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.
Author
Sichuan UniversityORCID 0000-0003-0985-0311Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
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Bin Sun, Jing Guo, Dong Yang…·Xudong Zhao
This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.
Cheng Cheng, Yangqian Li, Suyan Wang…·Weimin Li
This study characterizes the lung microbiome in health and respiratory diseases using metagenomic sequencing, identifying key species and functional pathways associated with different conditions.
Huan Wang, Jiarui Zhang, Jiaxun Zhang…·Dan Xie
This study shows that tumor-resident microbes like Bacillus mycoides and Pseudomonas veronii metabolize EGFR-TKIs, reducing their efficacy in NSCLC.
Xuan He, Jiajing Jiang, Guo Li…·Weimin Li
This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.
Dan Xie, Xia Lin, Zhoufeng Wang…·Weimin Li
The paper uses nanopore sequencing to analyze large-scale somatic insertions in NSCLC, identifying three key insertion patterns and their regulatory impacts.
Chun‐Xiao Song, Senlin Yin, Li Ma…·Stephen R. Quake
The paper analyzes 5-hydroxymethylcytosine in cell-free DNA to predict tumor types and stages with high accuracy.