Low oxygen promotes extravillous trophoblast progenitor expansion but restrains maturation
Gina L. McNeill, Giada Guntri, Ida Calvi, Alastair Hugh Kyle, Hans-Rudolf Hotz, Victoria M. Leonard, Wanying Wu, Matthew James Shannon, Andrew Ivor Minchinton, Keegan D. Korthauer, Margherita Yayoi Turco, Alexander G. Beristain
The paper shows low oxygen promotes EVT progenitor expansion but restricts their maturation, with HIF-1 playing a partial role in the maturation block.
bioRxiv · Oct 29, 2025 · PreprintDevelopmental Biology