Margherita Yayoi Turco

An organoid model of the menstrual cycle reveals the role of the luminal epithelium in regeneration of the human endometrium

This study uses an organoid model to show luminal epithelial cells drive endometrial regeneration through WNT7A and cell-cell communication during the menstrual cycle.

Low oxygen promotes extravillous trophoblast progenitor expansion but restrains maturation

The paper shows low oxygen promotes EVT progenitor expansion but restricts their maturation, with HIF-1 playing a partial role in the maturation block.

A model of apical-out human first trimester trophoblast organoids to study regeneration after syncytial damage

The paper develops an in vitro model of human first-trimester trophoblast organoids to study syncytiotrophoblast regeneration after damage and identifies TNFRSF12A as a potential enhancer of this process.

Successful placentation in human pregnancy is regulated by reciprocal interactions between maternal uterine NK cells and fetal placental trophoblast

The paper identifies a uNK-derived cytokine signal that promotes trophoblast differentiation and influences placental function and pregnancy outcomes.

Spatially resolved single-cell multiomics map of human trophoblast differentiation in early pregnancy

This study creates a spatially resolved single-cell multiomics atlas of human trophoblast differentiation in early pregnancy, revealing key regulatory programs and cell-cell communication events involved in EVT invasion and arterial transformation.

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

This study maps the temporal and spatial dynamics of the human endometrium using single-cell and spatial reference maps, identifying key signaling pathways regulating cell fate in vivo and in vitro.

BAP1/ASXL complex modulation regulates Epithelial-Mesenchymal Transition during trophoblast differentiation and invasion

This study shows that BAP1/ASXL complex modulation is essential for triggering EMT in trophoblast differentiation and invasion, with conserved function in mouse and human.

Reconstructing the human first trimester fetal-maternal interface using single cell transcriptomics

The paper profiles single-cell transcriptomes from the human first trimester fetal-maternal interface, revealing cellular composition and interactions critical for placentation.