Hans-Rudolf Hotz

The eutherian-specific histone H3.4 promotes germ cell development and reproductive fitness

This study shows that the eutherian-specific histone H3.4 variant promotes male germ cell development and reproductive fitness through specific sequence variations.

An organoid model of the menstrual cycle reveals the role of the luminal epithelium in regeneration of the human endometrium

This study uses an organoid model to show luminal epithelial cells drive endometrial regeneration through WNT7A and cell-cell communication during the menstrual cycle.

Low oxygen promotes extravillous trophoblast progenitor expansion but restrains maturation

The paper shows low oxygen promotes EVT progenitor expansion but restricts their maturation, with HIF-1 playing a partial role in the maturation block.

A model of apical-out human first trimester trophoblast organoids to study regeneration after syncytial damage

The paper develops an in vitro model of human first-trimester trophoblast organoids to study syncytiotrophoblast regeneration after damage and identifies TNFRSF12A as a potential enhancer of this process.

Molecular logic of neuromodulatory systems in the zebrafish telencephalon

The paper maps neuromodulatory systems in zebrafish telencephalon using transcriptomics, revealing cell type-specific GPCRs and neuropeptide combinations.

Galaxy Training: A Powerful Framework for Teaching!

The paper introduces Galaxy Training Network (GTN) as a framework for creating and sharing FAIR training materials for data analysis, with recent improvements to support educators and expand its use in various learning environments.

Expanding the Galaxy's reference data

The paper describes integrating refgenie into Galaxy to manage and share reference datasets, with tools for retrieval and a global repository for easy access.

A Single-cell RNA-seq Training and Analysis Suite using the Galaxy Framework

The paper introduces a Galaxy-based suite for scRNA-seq analysis, offering workflows, training resources, and tools for preprocessing, normalization, and clustering across 10x and alternative platforms.

Community-driven data analysis training for biology

The paper presents a community-driven framework for interactive data analytics training in life sciences, enabling researchers to learn through web-based computation without software installation.