Author

Gina L. McNeill

University of British Columbia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:clustering· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

Alexander G. BeristainiD· 4 shared Matthew James ShannoniD· 4 shared Bárbara CastellanaiD· 2 shared Jasmin WächteriD· 2 shared Jennet BaltayevaiD· 2 shared Alastair Hugh KyleiD· 1 shared Alison CampbelliD· 1 shared Amy BarrieiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersDevelopmental Biology

Alexander G. BeristainORCID

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4 papers

Recent·Most cited

Low oxygen promotes extravillous trophoblast progenitor expansion but restrains maturation

Gina L. McNeill, Giada Guntri, Ida Calvi, Alastair Hugh Kyle, Hans-Rudolf Hotz, Victoria M. Leonard, Wanying Wu, Matthew James Shannon, Andrew Ivor Minchinton, Keegan D. Korthauer, Margherita Yayoi Turco, Alexander G. Beristain

The paper shows low oxygen promotes EVT progenitor expansion but restricts their maturation, with HIF-1 playing a partial role in the maturation block.

bioRxiv · Oct 29, 2025 · PreprintDevelopmental Biology

A blastocyst-derived in vitro model of the human chorion

Luca C. Schwarz, Matthew James Shannon, Gina L. McNeill, Rina C. Sakata, Viviane Souza Rosa, K. Cheah, Laura Keller, Phil Snell, Leila Christie, Kay T. Elder, Anastasia Mania, Lauren Weavers, Rachel Gibbons, Tugce Pehlivan Budak, Ippokratis Sarris, , Marta N. Shahbazi

This paper develops an in vitro model of the human chorion using blastocysts to generate trophoblast organoids and extraembryonic mesoderm cells, enabling study of placental development and pathophysiology.

bioRxiv · Aug 6, 2025 · PreprintDevelopmental Biology

Single-cell assessment of trophoblast stem cell-based organoids as human placenta-modeling platforms

Matthew James Shannon, Gina L. McNeill, Burak Koksal, Jennet Baltayeva, Jasmin Wächter, Bárbara Castellana, Maria S. Peñaherrera, Wendy P. Robinson, Peter C. K. Leung, Alexander G. Beristain

The paper compares single-cell transcriptomes of trophoblast organoids derived from hTSCs and primary CTBs to in vivo trophoblasts, identifying similarities and differences in differentiation trajectories and cell states.

bioRxiv · Nov 2, 2022 · PreprintDevelopmental Biology

Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment

Matthew James Shannon, Jennet Baltayeva, Bárbara Castellana, Jasmin Wächter, Gina L. McNeill, Ji Soo Yoon, Jenna Treissman, Hoa Le, Pascal M. Lavoie, Alexander G. Beristain

The paper uses scRNA-seq to identify trophoblast states and lineage trajectories in first trimester placentas, finding BCAM as a marker of a primitive progenitor state.

Development · Jan 1, 2022Peer-reviewedDevelopmental Biology