Matthew James Shannon

The paper shows low oxygen promotes EVT progenitor expansion but restricts their maturation, with HIF-1 playing a partial role in the maturation block.

This paper develops an in vitro model of the human chorion using blastocysts to generate trophoblast organoids and extraembryonic mesoderm cells, enabling study of placental development and pathophysiology.

The paper compares gene expression differences between male and female extravillous trophoblasts using bulk and single-cell RNA sequencing across the first trimester, identifying autosomal gene differences emerging after week 10 of gestation.

The paper compares single-cell transcriptomes of trophoblast organoids derived from hTSCs and primary CTBs to in vivo trophoblasts, identifying similarities and differences in differentiation trajectories and cell states.

The paper uses single-cell RNA sequencing to map metzincin protease expression in human first trimester trophoblasts and identifies key proteases and their substrates in different differentiation states.

The paper uses scRNA-seq to identify trophoblast states and lineage trajectories in first trimester placentas, finding BCAM as a marker of a primitive progenitor state.