Direct and indirect RANK ligand and CD40 ligand signaling regulate the maintenance of thymic epithelial cell frequency and properties in the adult thymus
Mio Hayama, Hiroto Ishii, Maki Miyauchi, Masaki Yoshida, Naho Hagiwara, Wataru Muramtatu, Kano Namiki, Rin Endo, Takahisa Miyao, Nobuko Akiyama, Taishin Akiyama
This study shows that RANKL and CD40L signaling maintain mTEC frequency and TEC progenitor properties in the adult thymus through direct and indirect mechanisms.
Frontiers in Immunology · Nov 29, 2024Peer-reviewedImmunology