Masaki Yoshida

This study investigates the second impact of acute total body irradiation on thymic epithelial cells, finding reduced mTEC frequencies and altered gene expression during the second impact phase.

The paper identifies ASCL1 as a key regulator of mTEC function and central tolerance by analyzing single-cell RNA sequencing data from thymoma patients and mouse models.

This study shows that RANKL and CD40L signaling maintain mTEC frequency and TEC progenitor properties in the adult thymus through direct and indirect mechanisms.