Author

Hiroto Ishii

RIKEN

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Maki Miyauchi· 4 shared Naho Hagiwara· 4 shared Nobuko AkiyamaiD· 4 shared Rin Endo· 4 shared Taishin AkiyamaiD· 4 shared Takahisa Miyao· 4 shared Kano Namiki· 3 shared Masaki YoshidaiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Maki Miyauchi

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Second impact of an acute total body irradiation on thymic epithelial cells

Kano Namiki, Wataru Muramatsu, Takahisa Miyao, Hiroto Ishii, Rin Endo, Naho Hagiwara, Maki Miyauchi, Masaki Yoshida, Nobuko Akiyama, Taishin Akiyama

This study investigates the second impact of acute total body irradiation on thymic epithelial cells, finding reduced mTEC frequencies and altered gene expression during the second impact phase.

Heliyon · Jul 1, 2026Peer-reviewedImmunology

A chromatin relay from AIRE to ETS transcription factors sustains peripheral antigen expression in the thymic mimetic cells to ensure central tolerance.

Kenta Horie, Takahisa Miyao, Yuko Yamagata, Yuki Takakura, Fuyoko Suzuki, Naho Hagiwara, Rin Endo, Maki Miyauchi, Hiroto Ishii, Wataru Muramatsu, Yuki Goda, Tatsuya Ishikawa, Jun‐ichiro Inoue, Nobuaki Yoshida, N Yamaguchi, , Taishin Akiyama

The paper identifies EHF and ELF3 as key ETS transcription factors that sustain AIRE-primed gene expression in post-AIRE mimetic thymic epithelial cells, ensuring central tolerance.

bioRxiv · Feb 5, 2026 · PreprintImmunology

ASCL1 primes medullary thymic epithelial cell programs required for central tolerance

Nobuko Akiyama, Kenta Horie, Kano Namiki, Jen-Chien Chang, Maki Miyauchi, Takahisa Miyao, Nanako Uchida, Naho Hagiwara, Masaki Yoshida, Mizuki Morota, Tsukasa Kouno, Miki Kojima, Jonathan Moody, Yoshinari Ando, Hirotake Ichise, , Taishin Akiyama

The paper identifies ASCL1 as a key regulator of mTEC function and central tolerance by analyzing single-cell RNA sequencing data from thymoma patients and mouse models.

bioRxiv · Aug 6, 2025 · PreprintImmunology

Direct and indirect RANK ligand and CD40 ligand signaling regulate the maintenance of thymic epithelial cell frequency and properties in the adult thymus

Mio Hayama, Hiroto Ishii, Maki Miyauchi, Masaki Yoshida, Naho Hagiwara, Wataru Muramtatu, Kano Namiki, Rin Endo, Takahisa Miyao, Nobuko Akiyama, Taishin Akiyama

This study shows that RANKL and CD40L signaling maintain mTEC frequency and TEC progenitor properties in the adult thymus through direct and indirect mechanisms.

Frontiers in Immunology · Nov 29, 2024Peer-reviewedImmunology